A shortcut to the smaller fragment of pamamycin-607

✍ Scribed by Heiko Bernsmann; Margit Gruner; Roland Fröhlich; Peter Metz

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 96 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01044-9

✦ Synopsis

Starting from a key intermediate for the synthesis of the larger hydroxy acid constituent of pamamycin-607 (1), an efficient three-step route to the methyl ester of the smaller fragment of 1 involving a Yamaguchi lactonization with concomitant C(2) epimerization was developed. Alternatively, the methyl ester of the smaller hydroxy acid portion of 1 was prepared by direct C(2) epimerization.