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A short-term open trial of clomipramine in the treatment of patients with panic attacks

✍ Scribed by F. K. Judd; G. D. Burrows; P. F. Marriott; P. Farnbach; S. Blair-West; T. R. Norman

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
668 KB
Volume
6
Category
Article
ISSN
0885-6222

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✦ Synopsis

Clomipramine was used to treat 14 patients with panic attacks. Diagnosis was made according to DSM-111 criteria for agoraphobia with panic attacks or panic disorder uncomplicated. An open evaluation of the drug over an 8-week treatment period was conducted. A total of 10 patients completed the study. Clomipramine was effective in reducing the mean number of panic attacks, the greatest response being observed in the first 2 weeks of treatment. Findings on all outcome measures showed that clomipramine was also effective in alleviating depression secondary to panic attacks, non-specific aspects of anxiety and improving phobic avoidance. There was a suggestion that responders to treatment received lower doses of clomipramine than non-responders. Further studies are required to evaluate this issue and the role of clomipramine in the treatment of panic disorders.

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