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A Short Synthesis of a Thromboxane B2 Key Intermediate from(R)-2,3-Isopropylideneglyceraldehyde. γ-Lactones as Templates for Chemoselectivecis-Annulation of Pyranosides

✍ Scribed by Mulzer, Johann ;Graske, Klaus-Dieter ;Shanyoor, Mazin


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
559 KB
Volume
1995
Category
Article
ISSN
0947-3440

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✦ Synopsis


Thromboxane B2 key intermediate I Glyceraldehyde, (R)-isopropylidene I y-Lactones I cis-Annulation I Felkin Anh addition of vinyl cuprate A six-step synthesis of the bicyclic lactone pyranoside 1, which has served as a key intermediate in numerous syntheses of thromboxane Bl, from (R)-2,3-isopropylideneglyceral-*