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A short synthesis of 5,7-bis(dialkylamino)-2-methyl- 8 -hydroxyquinolines

✍ Scribed by George B. Okide


Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
21 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

The bromine atoms of the title compound were replaced by the requisite amino compound to afford the desired derivatives in high yields. Thus, six target compounds viz‐ bis(diethylamino)‐, bis(dibutylamino)‐, bis(dicyclohexylamino)‐, dipyrrolidino‐, dipiperidino‐, and dipiperazino‐derivatives were obtained and characterized by spectral and elemental analyses.


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## Abstract The synthesis of spiroketals from nitro ketones is described. Racemic __trans__‐2‐Methyl‐1,7‐dioxaspiro[5.5]undecane (1a), and 2,8‐dimethyl‐1,7‐dioxaspiro[5.5]undecane (1b) are synthesized as a mixture of __trans__, __trans__ and __trans__, __cis__ isomers in a ratio of 6.5:3.5 (separab