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A short stereoselective synthesis of disubstituted cyclic amino acids

โœ Scribed by Wolfgang Maison; Gunadi Adiwidjaja


Book ID
104251649
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
82 KB
Volume
43
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


A new synthetic route to enantiomerically pure disubstituted derivatives of cyclic amino acids is reported. Key step of this synthesis is an oxidative cleavage of azabicycloalkene precursors that are synthesized in enantiomerically pure form via aza-Diels-Alder reaction. A range of different disubstituted pipecolic acid derivatives has been synthesized and their structure has been evaluated by X-ray analysis.


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