A short and convergent synthesis of unsaturated macrodilactones

✍ Scribed by Florent Yvergnaux; Yves Le Floc'h; René Grée

• Book ID: 104212365
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 103 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)70707-6

✦ Synopsis

A simple and versatile approach to macrodiolides 1, using two consecutive Wittig reactions, is described.

Macrolide dilactone antibiotics are a very interesting class of natural products not only due to their structural features but also because of their useful biological properties 2,s. The