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A short and convenient synthesis and evaluation of the antiinfective properties of indoloquinoline alkaloids: 10H-Indolo[3,2-b]quinoline and 7H-indolo[2,3-c]quinolines

✍ Scribed by Jagan R. Etukala; E. V. K. Suresh Kumar; Seth Y. Ablordeppey

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
258 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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10__H__‐Indolo[3,2‐b]quinoline and 7H‐indolo[2,3‐c]quinoline have been synthesized in two steps using a modified approach to our previous reported method. Starting from commercially available 3‐aminoquinoline and phenylboronic acid, the first step involved a copper acetate‐catalyzed coupling reaction and the second utilized a palladium acetate‐catalyzed intramolecular arylation reaction in the presence of trifluoroacetic acid as solvent. The anti‐infective activity of a selected number of the compounds was also evaluated.

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