✦ LIBER ✦

A serum factor capable of stimulating hyaluronic acid synthesis in cultured rat fibroblasts

✍ Scribed by Mikio Tomida; Hideki Koyama; Tetsuo Ono

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 472 KB
Volume: 91
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040910217

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Calf serum as well as rat and mouse sera has a factor that stimulates hyaluronic acid synthesis in cultured rat fibroblasts. Such a factor was partially purified from calf serum and characterized. It has a molecular weight of approximately 150,000. The activity of the factor is lost by treatment with pronase and by periodate oxidation. It is suggested, therefore, that the factor is a glycoprotein. Its susceptibility to α‐mannosidase and affinity for Con A‐Sepharose may suggest that the factor contains a mannose residue(s) which is essential for the activity to induce hyaluronic acid synthesis.

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