A series of new C2-symmetric amino alcohols with multicoordination groups: Promising catalysts for synthesis of both enantiomers in the borane-mediated reduction of prochiral ketones

Synthesis of a new C2-symmetric chiral c

Synthesis of a new C2-symmetric chiral catalyst and its application in the catalytic asymmetric borane reduction of prochiral ketones

✍ Yan Zhou; Wen-Hua Wang; Wei Dou; Xiao-Liang Tang; Wei-Sheng Liu 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB 👁 1 views

## Abstract A new __C__~2~‐symmetric chiral catalyst 3,5‐bis[(2__S__)‐(hydroxy‐diphenylmethyl)‐ pyrrolidin‐1‐ylmethyl]‐1,3,4‐oxadiazole was successfully synthesized by the reaction of 2,5‐dichloromethyl‐1,3,4‐oxadiazole with (__S__)‐α,α‐diphenyl‐2‐pyrrolidinemethanol, and applied to the catalytic a