A series of contributions to the question of the relation between chemical constitution and local anesthetic activity. IV. Local anesthetics containing an ephedrine-like nucleus

✍ Scribed by Lott, W.A. ;Christiansen, W.G.

• Publisher: Elsevier
• Year: 1939
• Weight: 279 KB
• Volume: 28
• Category: Article
• ISSN: 0898-140X
• DOI: 10.1002/jps.3080280808

✦ Synopsis

A 143.8-144.4 Benzene CIBH,IOZNCI 4.30 4.23 8-Diethylaminoethyl (a-n-propyl) A 125-126 Acetone-CnH~~0rh'Cl 4.30 4 5 4 8-IXethylaminoethyl (a-isopropyl) B 152-153 Benzene CnHr~09NCl 4.30 4.63 @-Diethylaminoethyl (a-n-hutyl) B 105.5-106.5 Acetone C~rHmOih'CI 4.12 4.16 @-Diethylaminoethyl (a-n-amyl) B 83-85 Acetone C s H & x N C I 3.96 4.26 EtOH Ether Ring Substituted Dialkylaminoalkyl a-AIkyl-Cinnamate Hydrochloride 8-Uiethylaminoethyl (a-ethyl)-u-A 127.5--128 Acetone CnlIdzNClr 4.04 4 -32 &Diethylaminoethyl (a-ethyl)-p-B 170-171 Acetone-Abs. CieHalOtNrCI 7.87 7.95 7-Diethylaminopropyl (u-ethyl)-A 191-192 Abs. EtOH-C~aHloO?NrClr 7.42 7.54 y-Diethylaminopropyl (a-ethyl)-A 170-170.5 Abs. EtOH-CI,HIOGN*CI? 7.42 . . chloro dimethylamino EtOH p-amino Ether o-amino Ether Dialkylaminoalkyl (,3-Alkyl)-Cinnamate Hydrochloride &Diethylaminoethyl (P-methyl) C 141-142 Abs. EtOH CiaHrOrNCI 4.70 4.85