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A sensitive LC/MS/MS bioanalysis assay of orally administered lipoic acid in rat blood and brain tissue

✍ Scribed by Hui Ting Chng; Lee Sun New; Aveline H. Neo; Catherine W. Goh; Edward R. Browne; Eric C.Y. Chan

Book ID
108189712
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
291 KB
Volume
51
Category
Article
ISSN
0731-7085

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## Abstract A simple, sensitive and specific LC‐MS/MS method for the determination of lipoic acid was developed and validated over the linearity range 5–1000 ng/mL (__r__^2^ > 0.99) with 200 Β΅L rat plasma using rosigliatzone as an internal standard (IS). The assay procedure involved a simple one‐st