A Semiparametric Response Surface Model for Assessing Drug Interaction
β Scribed by Maiying Kong; J. Jack Lee
- Book ID
- 109223801
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 562 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0006-341X
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π SIMILAR VOLUMES
For the purpose of drug surveillance, i.e., for continuous evaluation of possible associations between drugs and pathological manifestations (events), a response time model is suggested which involves the time of first drug administration and the event appearance time. Explicit parameter estimates c
## Abstract This paper formulates a likelihoodβbased estimator for a doubleβindex, semiparametric binary response equation. A novel feature of this estimator is that it is based on density estimation under local smoothing. While the proofs differ from those based on alternative density estimators,