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A semiempirical study of pyrazole acylhydrazones as potential antimalarial agents

✍ Scribed by Carlos M. R. De Sant'anna; Ricardo Bicca De Alencastro; Carlos R. Rodrigues; Gabriela Barreiro; Eliezer J. Barreiro; Joaquim Delphino Da Motta Neto; Antônio Carlos C. Freitas

Book ID
102655053
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
624 KB
Volume
60
Category
Article
ISSN
0020-7608

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✦ Synopsis

In this work, we evaluated structural and electronic similarities between a new class of acylhydrazones, recently presented as effective inhibitors of a Plasmodium falciparum cysteine protease, and a series of pyrazole arylacylhydrazones with analgesic and antiaggregating (antithrombotic) properties, using AM1. The calculated results suggest that at least one of the pyrazole compounds is similar enough to the active compounds to be considered as a candidate for a future antimalarial series.

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✍ Michael J. Pitt; Christopher J. Easton; Thomas A. Robertson; Lakshmi M. Kumarati 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 241 KB

Hydroperoxide derivatives of [~-oxa-substituted polyunsaturated fatty acids were prepared by 15-1ipoxygenase catalysed oxidation and perketal derivatives of fatty acid hydroperoxides were synthesized. The perketals are more stable than their parent fatty acid hydroperoxides, but less active as antim