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A self-adjusting carbohydrate ligand for GalNAc specific lectins

✍ Scribed by Shin Sakai; Yoshihiro Shigemasa; Tomikazu Sasaki

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
205 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Dynamic molecular recognition of synthetic carbohydrate ligands by lectins is described.

When bipyridine-modified GalNAc is reacted with Fe(ll), four diastereomers of the trivalent GalNAc ligand are formed in dynamic equilibrium at room temperature. The equilibrium allows the three GalNAc residues to adjust their spatial orientation on the metal template to fit into the binding pocket of various GalNAc-specific lectins.

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Structural basis for the carbohydrate-specificity of basic winged-bean lectin and its differential affinity for Gal and GalNAc
✍ Kulkarni, Kiran A. ;Katiyar, Samiksha ;Surolia, Avadhesha ;Vijayan, Mamannamana πŸ“‚ Article πŸ“… 2006 πŸ› International Union of Crystallography 🌐 English βš– 607 KB

The crystal structure of the complexes of basic winged-bean lectin with galactose, 2-methoxygalactose, N-acetylgalactosamine and methyl-alpha-N-acetylgalactosamine have been determined. Lectin-sugar interactions involve four hydrogen bonds and a stacking interaction in all of the complexes. In addit