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A Selective Human H 4 -Receptor Agonist: (−)-2-Cyano-1-methyl-3-{(2 R ,5 R )-5- [1 H -imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine

✍ Scribed by Hashimoto, Takeshi; Harusawa, Shinya; Araki, Lisa; Zuiderveld, Obbe P.; Smit, Martine J.; Imazu, Tomonari; Takashima, Seiichiroh; Yamamoto, Yumiko; Sakamoto, Yasuhiko; Kurihara, Takushi; Leurs, Rob; Bakker, Remko A.; Yamatodani, Atsushi

Book ID
121787382
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
60 KB
Volume
46
Category
Article
ISSN
0022-2623

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## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l