๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

A search for viruses and mycoplasmas in connective tissue diseases

โœ Scribed by Dr. Donald A. Person; John T. Sharp; William E. Rawls

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
571 KB
Volume
16
Category
Article
ISSN
0004-3591

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โœฆ Synopsis

Abstract

Taking advantage of the distinctive buoyant densities of viral and mycoplasmal nucleic acids, methods were developed for detecting a noncytolytic virus or mycoplasma in synovial cell cultures. No evidence of viral or mycoplasmal infection was found in the study of 20 cell strains derived from 13 patients with rheumatoid arthritis, 3 patients with noninflammatory joint disease, and one patient each with Reiter's syndrome, Behcet's syndrome, vasculitis with hepatitis 6 antigenemia, and ankylosing spondylitis with peripheral arthritis. Further, neither the treatment of synovialโ€VERO cocultured cells with 5โ€iodoโ€2'โ€deoxyuridine in dimethyl sulfoxide nor radiolabeling at the time of explanation permitted the detection of a virus or mycoplasma.

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