✦ LIBER ✦

A Search for Rheumatoid Arthritis-Associated Nuclear Antigen And Epstein-Barr Virus Specific Antigens or Genomes in Tissues and Cells from Patients with Rheumatoid Arthritis

✍ Scribed by Margaret A. Alspaugh; Hiromu Shoji; Meihan Nonoyama

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 849 KB
Volume: 26
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780260603

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✦ Synopsis

Pannus extracts and/or cells and tissues from rheumatoid arthritis (RA) patients and controls were tested for the presence of RA-associated nuclear antigen (RANA), anti-RANA, Epstein-Barr virus (EBV)-specific antigens, and EBV genomes. Using our present rather insensitive methods, RANA was rarely detected in RA pannus extracts or tissues, whereas anti-RANA was commonly found. EBV-specific antigens or genomes could not be detected in a limited number of tissues tested using our present methods. The data suggest that EBV may not be the primary event causing RA through direct infection and transformation of synovial tissues.

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