A Screening Strategy for Selection of Anti-HSV-1 and Anti-HIV Extracts from Algae
✍ Scribed by Kyoko Hayashi; Jin Hamada; Toshimitsu Hayashi
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 507 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
No coin nor oath required. For personal study only.
✦ Synopsis
In order to find new sources of antiviral agents with different mechanisms of action, extracts of 49 algae were assayed for antiherpes simplex virus (HSV) and anti-human immunodeficiency virus (HIV) activities. Twenty-five aqueous extracts showed anti-HSV activity, four of which were found to be most potent inhibitors with a selective index more than 1000. Eight samples of the aqueous extracts were identified as having activity against HIV replication. The result suggests that the extracts from algae are a promising source of antiviral agents which may act on different stages in virus replication cycle.