A Scintillation Proximity Assay Amendable for Screening and Characterization of DNA Gyrase B Subunit Inhibitors: Volume 300, Number 1 (2002), pages 34–39

A Scintillation Proximity Assay Amenable

A Scintillation Proximity Assay Amenable for Screening and Characterization of DNA Gyrase B Subunit Inhibitors

✍ Monica Gevi; Enrico Domenici 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 114 KB

DNA gyrase is the target of coumarin and cyclothialidine antibacterials, which bind to the B subunit of the enzyme (GyrB). Currently available GyrB inhibitors have not been clinically successful, but their high in vitro potency against DNA gyrase has raised interest in the development of novel nonco