✦ LIBER ✦

A scavenger that really scavenges is better in the liver than in the artery

✍ Scribed by A D Cooper

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 152 KB
Volume: 23
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.510230438

No coin nor oath required. For personal study only.

✦ Synopsis

A SCAVENGER THAT REALLY SCAVENGES IS tury ago. However, the precise steps that lead to the deposition of LDL cholesterol in the artery have not BETTER IN THE LIVER THAN IN THE ARTERY been fully elucidated. Brown and Goldstein's Nobel Wolle S, Via DP, Chan L, Comicelli JA, Bisgaier CL. Prize-winning work 1 established that a specific pro-Hepatic overexpression of bovine scavenger receptor tein, the LDL receptor, is responsible for the removal type I in transgenic mice prevents diet-induced hyperof LDL from the blood, and most of this activity is in betalipoproteinemia. J Clin Invest 1995;96:260-272. the liver. The hallmark of early atherosclerosis is the formation of foam cells, lipid-laden macrophages, in ABSTRACT the artery wall. How then does cholesterol, presumably from LDL, get into macrophages in the artery wall? A Hepatic scavenger receptors (SR) may play a protecfirst thought would be via LDL receptors, which are

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