A Safe and Efficient Process for the Syn
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Ramakrishna, Kornpati; Behme, Chris; Schure, Ralph M.; Bieniarz, Christopher
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Article
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2000
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American Chemical Society
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English
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A novel method for the synthesis of 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane (sevoflurane) is described. Starting from commercially available 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), the process involves a novel, safe and efficient fluoromethylation protocol in a two-step, one-vessel procedu