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A Safe and Efficient Process for the Synthesis of the Inhalation Anesthetic Sevoflurane

โœ Scribed by Ramakrishna, Kornpati; Behme, Chris; Schure, Ralph M.; Bieniarz, Christopher


Book ID
121500806
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
42 KB
Volume
4
Category
Article
ISSN
1083-6160

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A Safe and Efficient Process for the Syn
โœ Ramakrishna, Kornpati; Behme, Chris; Schure, Ralph M.; Bieniarz, Christopher ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 42 KB

A novel method for the synthesis of 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane (sevoflurane) is described. Starting from commercially available 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), the process involves a novel, safe and efficient fluoromethylation protocol in a two-step, one-vessel procedu