A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

✍ Scribed by Alesia A. Miloslavina; Enrico Leipold; Michael Kijas; Annegret Stark; Stefan H. Heinemann; Diana Imhof

• Book ID: 105359741
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 169 KB
• Volume: 15
• Category: Article
• ISSN: 1075-2617
• DOI: 10.1002/psc.1106

✦ Synopsis

Abstract

We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1‐ethyl‐3‐methylimidazolium acetate ([C~2~mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water‐soluble conotoxins compared with conventional methods. Moreover, the method features a high‐concentration approach ultimately leading to higher yields at reduced separation effort. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.