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A role for topical 5-fluorouracil therapy in melanoma

✍ Scribed by Robert F. Ryan; Edward T. Krementz; Martin S. Litwin

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
886 KB
Volume
38
Category
Article
ISSN
0022-4790

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✦ Synopsis

Topical 5-fluorouracil (Efudex@) has been shown to be of great value in the treatment of skin cancers, Marjolin ulcers, and advanced squamous cell carcinoma of the mouth and esophagus. It has been advocated for use on patients with melanocytic dysplasia and lentigo maligna melanoma. This report confirms the use of topical 5-FU for lentigo maligna melanoma and melanocytic dysplasia. In melanomas with poor prognosis, preoperative treatment with topical 5-FU converts the cellular infiltrate from acute inflammatory cells to round cells which have been shown to be T-cells. We believe this preoperative stimulation of the patients' own immune reaction to the tumor may be of great significance in improving the surgical results for melanomas with a poor prognosis.

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