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A role for the phosphatidylinositol 3-kinase – protein kinase C zeta – Sp1 pathway in the 1,25-dihydroxyvitamin D3 induction of the 25-hydroxyvitamin D3 24-hydroxylase gene in human kidney cells

✍ Scribed by Prem P. Dwivedi; Xiu-Hui Gao; Joseph Cheng-Ta Tan; Andreas Evdokiou; Antonio Ferrante; Howard A. Morris; Brian K. May; Charles S.T. Hii

Book ID: 113528370
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 729 KB
Volume: 22
Category: Article
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2009.11.009

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## Abstract In this article we show that 1α,25‐dihydroxyvitamin D~3~ (1α,25(OH)~2~D~3~) stimulates the activity of the class IA phosphatidylinositol 3‐kinase PI3Kα and its downstream target Akt in HL60, U937 and THP‐1 myeloid leukaemic cell lines. Furthermore, we show that the classical nuclear vit