A role for the mesolimbic dopamine system in the reinforcing properties of diazepam
β Scribed by C. Spyraki; H. C. Fibiger
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 562 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
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In this review we will critically assess the hypothesis that the reinforcing effect of virtually all drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system. The focus is on five classes of abused drugs: psychostimulants, opiates, ethanol, cannabinoids and nicotine. For
Diazepam self-administration was studied in rhesus monkeys under several conditions of availability. Leverpress responding was maintained in twelve monkeys under a fixed-ratio 10 (FR 10) schedule of IV cocaine or pentobarbital delivery in daily sessions of 1-3 h duration. Each of several doses of di