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A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

✍ Scribed by Mohan Viswanathan; Stuart K. Kim; Ala Berdichevsky; Leonard Guarente


Book ID
116403945
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
421 KB
Volume
9
Category
Article
ISSN
1534-5807

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## Abstract BAG‐1 (Bcl‐2 associated athanogene‐1) is a multifunctional protein, linking cell proliferation, cell death, protein folding, and cell stress. In vivo, BAG‐1 is expressed in growth plate and articular cartilage, and the expression of BAG‐1 is decreased with aging. Chondrocytes respond to