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A role for metals and free radicals in the induction of apoptosis in thymocytes

✍ Scribed by James T. Wolfe; David Ross; Gerald M. Cohen

Book ID
115929379
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
916 KB
Volume
352
Category
Article
ISSN
0014-5793

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Administration of concanavalin A (Con A) is a well-established model of acute immune-mediated hepatitis. Here, we demonstrate that intravenous injection of Con A in mice induces profound thymic atrophy. Compared to liver damage, the kinetics of Con A-induced thymic atrophy is slower and more prolong