A role for lymphotoxin β receptor in host defense against Mycobacterium bovis BCG infection

Severe Mycobacterium bovis BCG infection

Severe Mycobacterium bovis BCG infections in a large series of novel IL–12 receptor β1 deficient patients and evidence for the existence of partial IL–12 receptor β1 deficiency

✍ Elgin G. R. Lichtenauer-Kaligis; Tjitske de Boer; Frank A. W. Verreck; Sjaak van 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB 👁 1 views

Cell mediated immunity plays a critical role in human host defence against intracellular bacteria. In patients with unusual, severe infections caused by poorly pathogenic species of mycobacteria and salmonellae, genetic deficiencies have been identified in key genes in the type-1 cytokine pathway, e