In mammals, the final number of oocytes available for reproduction of the next generation is defined at birth. Establishment of this oocyte pool is essential for fertility. Mammalian primordial germ cells form and migrate to the gonad during embryonic development. After arriving at the gonad, the ge
A role for Lin28 in primordial germ-cell development and germ-cell malignancy
β Scribed by West, Jason A.; Viswanathan, Srinivas R.; Yabuuchi, Akiko; Cunniff, Kerianne; Takeuchi, Ayumu; Park, In-Hyun; Sero, Julia E.; Zhu, Hao; Perez-Atayde, Antonio; Frazier, A. Lindsay; Surani, M. Azim; Daley, George Q.
- Book ID
- 109898333
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 982 KB
- Volume
- 460
- Category
- Article
- ISSN
- 0028-0836
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## Abstract Recent studies demonstrate that the normal progression of the germ cell lineage during gonadogenesis involves a delicate balance of primordial germ cell survival and death factors generated by surrounding somatic cells. This balance operates in a different fashion in females and males.