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A role for iron in Wnt signalling

✍ Scribed by Brookes, M J; Boult, J; Roberts, K; Cooper, B T; Hotchin, N A; Matthews, G; Iqbal, T; Tselepis, C

Book ID
110072701
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
185 KB
Volume
27
Category
Article
ISSN
0950-9232

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Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. Here we show that the Wnt signalling pathway has an important role in this process. Overexpression of activated bet