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A role for glycosphingolipid-enriched microdomains in platelet glycoprotein Ib-mediated platelet activation

โœ Scribed by W. JIN; O. INOUE; N. TAMURA; K. SUZUKI-INOUE; K. SATOH; M. C. BERNDT; M. HANDA; S. GOTO; Y. OZAKI


Book ID
109152053
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
723 KB
Volume
5
Category
Article
ISSN
1538-7933

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A role for PLCฮณ2 in platelet activation
โœ Giuliana Leoncini; Debora Bruzzese; Maria Grazia Signorello ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 265 KB

## Abstract The aim of this study was to examine the homocysteine effect on phospholipase Cฮณ2 (PLCฮณ2) activation and to investigate the signaling pathway involved. We found that homocysteine stimulated the tyrosine phosphorylation and activation of platelet PLCฮณ2. The tyrosine kinases p60src and p7