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A Role for Cytochrome b5 in the In Vivo Disposition of Anticancer and Cytochrome P450 Probe Drugs in Mice

✍ Scribed by Henderson, C. J.; McLaughlin, L. A.; Finn, R. D.; Ronseaux, S.; Kapelyukh, Y.; Wolf, C. R.

Book ID
121860522
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2013
Tongue
English
Weight
948 KB
Volume
42
Category
Article
ISSN
0090-9556

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## Abstract Cytochrome __b__~5~, a 17‐kDa hemeprotein associated primarily with the endoplasmic reticulum of eukaryotic cells, has long been known to augment some cytochrome P450 monooxygenase reactions, but the mechanism of stimulation has remained controversial. Studies in recent years have clari