## Abstract Hypoxia‐inducible factor‐1 (HIF‐1) is a heterodimeric transcription factor that plays a major role in cellular adaptation to hypoxia. The mechanisms regulating HIF‐1 activity occurs at multiple levels __in vivo__. The HIF‐1α subunit is highly sensible to oxygen and is rapidly degraded b
A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity
✍ Scribed by Rongtuan Lin; Rongtuan Lin; John Hiscott; John Hiscott; John Hiscott
- Book ID
- 110242123
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 180 KB
- Volume
- 191
- Category
- Article
- ISSN
- 0300-8177
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
This study documented casein kinase II (CK II) activity in Acheta domesticus brain using specific antibodies and its regulation by polyamines. In control animals a transient decrease in CK II activity at day 3 after imaginal moult was observed in the brain but not in the fat body. If deprived of ecd
## Abstract The role of c‐Jun NH~2~‐terminal kinase (JNK) signaling cascade in the stress‐inducible phosphorylation of heat shock factor 1 (HSF1) was investigated using known agonists and antagonists of JNK. We showed that treatment of HeLa cells with MG132, a proteasome inhibitor and known JNK act
## Abstract The generation of contractile force mediated by actin‐myosin interactions is essential for cell motility. Myosin activity is promoted by phosphorylation of myosin light chain (MLC). MLC phosphorylation in large part is controlled by kinases that are effectors of Rho family GTPases. Acco
## Abstract The antioxidant‐activated transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We r
Cyclin-dependent kinase inhibitors play a significant role in cell cycle progression and in cellular differentiation and their expression is regulated in different cellular settings. GC-rich regions in the promoter sequences of the cyclin-dependent kinase inhibitor genes p15INK4B and p21CIP1/WAF1 me