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A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis

✍ Scribed by Luis H. Barbeito; Mariana Pehar; Patricia Cassina; Marcelo R. Vargas; Hugo Peluffo; Liliana Viera; Alvaro G. Estévez; Joseph S. Beckman

Book ID
116327522
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
263 KB
Volume
47
Category
Article
ISSN
0165-0173

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Astrocytic proliferation and hypertrophy (astrogliosis) are associated with neuronal injury. However, neither the temporal nor the spatial relationship between astrocytes and injured neurons is clear, especially in neurodegenerative diseases. We investigated these questions in a mouse amyotrophic la