A risk model for ovarian carcinoma patients using CA 125: Time to normalization renders second-look laparotomy redundant
✍ Scribed by Giuseppe Frasci; Salvatore Conforti; Fulvio Zullo; Pasquale Mastrantonio; Giuseppe Comella; Pasquale Comella; Giovanni Persico; Rosario Vincenzo Iaffaioli
- Book ID
- 102649349
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 706 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
We evaluated the incorporation of CA 125 normalization times into a prognostic model based on pretreatment variables in patients with ovarian carcinoma to determine if they could render second-look laparotomy (SLL) redundant.
METHODS.
A total of 54 consecutive patients with ovarian carcinoma who underwent SLL between 1985 and 1990 were included in this analysis. At diagnosis, all of the patients had abnormal CA-125 serum levels, which fell to within the normal range during chemotherapy. Cox's model was used to select pretreatment variables relevant for prognosis. The influence of the time to normalization of CA 125 (5 vs. z 1 months) and the capability of SLL results to modify prognostic prediction, were also evaluated.
RESULTS. The size of the residual tumor at the beginning of therapy, and Eastern
Cooperative Oncology Group (ECOG) performance status (PS) were independently predictive of survival. The time to normalization of CA 125 serum levels (analyzed either as a continuous or as a two-category variable) also had an independent prognostic role when included in the model. When we examined the inclusion of both CA 125 parameter and SLL into the model together, we found that only CA 125 continued to have an independent prognostic relevance. On the basis of the