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A review of the design, synthesis and biological activity of the bicyclic hexapeptide tachykinin NK2 antagonist MEN 10627

✍ Scribed by Laura Quartara; Vincenzo Pavone; Carlo Pedone; Angelina Lombardi; Anna Rita Renzetti; Carlo Alberto Maggi


Book ID
116104571
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
473 KB
Volume
65
Category
Article
ISSN
0167-0115

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The large-scale solid-phase continuous flow synthesis of the bicyclic peptide MEN 10627, a new potent Neurokinin A receptor antagonist, is described using the Fmoc-polyamide method on both Macrosorb 125 and Macrosorb 250 resin. A new synthesizer designed in-house was realized by assembling Whitey va