Background: A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP) association study identified ATG16L1 as a Crohn's disease (CD) susceptibility gene. The association appeared to be confined to the nsSNP rs2241880 and was confirmed in 2 German independent case-control collections
A review of major Crohn’s disease susceptibility genes and their role in disease pathogenesis
✍ Scribed by Meghan Barrett; Sathees B. Chandra
- Publisher
- The Genetics Society of Korea
- Year
- 2011
- Tongue
- English
- Weight
- 272 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1976-9571
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Background: Genetic susceptibility may play a more important role in the etiology of early-onset inflammatory bowel disease (IBD) than in late-onset IBD, and therefore pediatric-onset IBD patients can be expected to have a higher frequency of gene mutations. We aimed to determine genotypes and pheno
Background: Genome-wide association studies (GWAS) and replication studies have shown conflicting associations between the NELL1, NCF4, and FAM92B genes and susceptibility for Crohn's disease (CD). We sought to examine whether these genes were associated with CD in Canadian children and young adults
Background: With improvements in therapy for inflammatory bowel disease (IBD) and changes in the prevalence of obesity, the phenotype of Crohn's disease (CD) is changing. These changes may herald an increase in the incidence of nonalcoholic fatty liver disease (NAFLD) in this population. Methods: O