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A reversible protecting group for the amide bond in peptides. Use in the synthesis of ?difficult sequences?

โœ Scribed by Johnson, T.; Quibell, M.; Owen, D.; Sheppard, R. C.


Book ID
111859998
Publisher
The Royal Society of Chemistry
Year
1993
Tongue
English
Weight
365 KB
Volume
4
Category
Article
ISSN
0022-4936

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๐Ÿ“œ SIMILAR VOLUMES


Use of the vinyloxycarbonyl group for am
โœ R.A. Olofson; Y.Stephen Yamamoto; David J. Wancowicz ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 252 KB

In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t