A retrospective study of treatment of cerebral toxoplasmosis in AIDS patients with trimethoprin-sulphamethoxazole

✍ Scribed by D. Torre; F. Speranza; F. Martegani; C. Zeroli; M. Banfi; M. Airoldi

• Book ID: 108407657
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 382 KB
• Volume: 37
• Category: Article
• ISSN: 0163-4453
• DOI: 10.1016/s0163-4453(98)90217-1

✦ Synopsis

Aims of the study:

A retrospective study was designed to evaluate efficacy and tolerance of trimethoprim-sulphamethoxazole (tmp-smz) in aids patients with cerebral toxoplasmosis (te).

Patients and methods:

We reviewed 471 patients with aids, and we analysed 71 aids patients with te, who received intravenous therapy with tmp-smz (tmp: 10 mg/kg/day, smz: 50 mg/kg/day) for 4 weeks.

Results:

35 patients (49.2%) had a complete regression of clinical signs, and a complete resolution of radiological lesions was noted in 41 patients (57.7%). improvement of clinical signs and radiological lesions were observed in 27 patients (38%), and in nine patients (12.6%), respectively. in contrast, nine patients (12.6%) did not show any clinical change, or worsened. twenty-two patients (30.9%) suffered from adverse cutaneous reactions, whereas many patients had haematological toxicity.

Conclusions:

Tmp-smz seems to be an efficient therapy for te in aids patients, although further prospective, randomized therapeutic trials are required to confirm these results.