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A retro-inverso TAT-like peptide designed to deliver cysteamine to cells

✍ Scribed by Jongdoo Lim; Jean-Philippe Pellois; Eric E. Simanek

Book ID: 104004653
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 310 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.07.046

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✦ Synopsis

A retro-inverso, TAT-like peptide wherein lysine residues are replaced with cysteine residues bearing a disulfide-linked cysteamine group is found to engage in thiol-disulfide exchange with cysteine. These peptides are transported into cells and localize to lysosomes. Cellular uptake is enhanced in peptides bearing two cysteamine groups over those with one or none, by factors of approximately 1.5 and 12, respectively.

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