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A response to ‘The thienopyridine derivatives (platelet adenosine diphosphate receptor antagonists), pharmacology and clinical developments’, Kam PCA, Nethery CM, Anaesthesia 2003; 58: 28–35.

✍ Scribed by R. Self

Book ID: 104457017
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 80 KB
Volume: 58
Category: Article
ISSN: 0003-2409
DOI: 10.1046/j.1365-2044.2003.03236_10.x

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The thienopyridine derivatives (platelet

The thienopyridine derivatives (platelet adenosine diphosphate receptor antagonists), pharmacology and clinical developments

✍ P. C. A. Kam; C. M. Nethery 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB

**Summary** The thienopyridines, ticlopidine and clopidogrel, are antiplatelet drugs. They are prodrugs and are metabolised in the liver to active metabolites that are non‐competitive antagonists of the platelet adenosine diphosphate receptor, P2Y~12~. Inhibition of platelet aggregation by these dru