A Report on the Oxidative Degradation of Neutralized Carbopol * *University of California School of Pharmacy, San Francisco 22

✍ Scribed by Schwarz, T.W. ;Levy, Gerhard

• Publisher: Elsevier
• Year: 1958
• Weight: 168 KB
• Volume: 47
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030470617

✦ Synopsis

Neutralized Carbopol 934 gels undergo oxidative degradation when exposed to daylight. This reaction is probably catalyzed by trace metals. EDTA, various nonelectrolyte antioxidants and poly-hydroxy compounds may be used to retard this degradation.

N IMPORTANT REQUIREMENT for pharmaceu-. .