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A repetitive sequence element 3′ of the human c-Ha-ras1 gene has enhancer activity

✍ Scribed by Justus B. Cohen; Maureen V. Walter; Arthur D. Levinson

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
622 KB
Volume
133
Category
Article
ISSN
0021-9541

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✦ Synopsis

Efficient expression of the h u m a n c-Ha-rasl gene requires sequences 3' of those specifying the polyadenylation of its transcripts. These sequences can stimulate the expression of heterologous genes in a manner largely independent of position and orientation, arguing that they possess a transcriptional enhancing activity that regulates the c-Ha-rasl promoter. As this element is associated with a repetitive domain that is highly polymorphic, it is possible that the activity of this enhancer i s variable within the human population.

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