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A remote control process for the routine synthesis of branched chain [1-11C]α amino acids

✍ Scribed by John D. Fissekis; Christopher M. Nielsen; Sebastian Tirelli; Anthony F. Knott; J.Robert Dahl


Publisher
Elsevier Science
Year
1991
Weight
903 KB
Volume
42
Category
Article
ISSN
0883-2889

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Alternative procedure for the synthesis
✍ Martı́n A. Iglesias-Arteaga; Elena Castellanos; Eusebio Juaristi 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 177 KB

The title heterocycle is prepared in enantiomerically pure form and in 46-50% overall yield from (S)-asparagine, a readily available starting material. The synthetic route described in this report represents a major improvement over the original procedure (Tetrahedron: Asymmetry 1991, 3, 723), that