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A remarkable room temperature preparation of the trifluorovinylzinc reagent from HFC-134a. A cost-effective, high yield synthesis of α,β,β-trifluorostyrenes

✍ Scribed by R Anilkumar; Donald J Burton

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 96 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00397-0

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✦ Synopsis

The reaction of LDA (2.0 equiv.) with a THF solution of ZnCl 2 (1.0 equiv.) and CF 3 CFH 2 (HFC-134a) (1.2 equiv.) at 15-20°C gives a 73% yield of [F 2 C CFZnCl]. Addition of R-C 6 H 4 I and Pd(PPh 3 ) 4 at rt to 65°C gives 61-86% yield of R-C 6 H 4 CF CF 2 .

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