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A reliable method of liquid chromatography for the quantification of acetaminophen and identification of its toxic metabolite N-acetyl-p-benzoquinoneimine for application in pediatric studies

✍ Scribed by Carmen Flores-Pérez; Juan Luis Chávez-Pacheco; Blanca Ramírez-Mendiola; Radamés Alemón-Medina; Raquel García-Álvarez; Hugo Juárez-Olguín; Janett Flores-Pérez

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 350 KB
Volume: 25
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.1511

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## Abstract A sensitive, selective, specific and rapid liquid chromatographic/electrospray ionization tandem mass spectrometric assay method was developed and validated for the simultaneous quantitation of α‐,β‐arteether (α‐,β‐AE) and its metabolite α‐dihydroartemisinin (DHA) in monkey plasma using