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A reinterpretation of tyramine sympathomimetic effect and tachyphylaxis

✍ Scribed by Prof. M. Raiteri; G. Levi

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
187 KB
Volume
16
Category
Article
ISSN
0360-4012

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✦ Synopsis

In this commentary, the indirect sympathomimetic effect of tyramine and the phenomenon of tyramine tachiphylaxis are reinterpreted in terms of carriermediated exchange processes. Extracellular tyramine would exchange with intraterminal noradrenaline and, upon repeated tyramine administration, with a mixture of noradrenaline and tyramine progressively more enriched in the pharmacologically inactive amine.

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