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A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity

✍ Scribed by Brown, S M; Peet, E; Manuck, S B; Williamson, D E; Dahl, R E; Ferrell, R E; Hariri, A R


Book ID
110059999
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
121 KB
Volume
10
Category
Article
ISSN
1359-4184

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Dopamine ␀-hydroxylase (DBH), the enzyme that converts dopamine to norepinepherine, has been proposed as being involved in the aetiology of schizophrenia. Previous work identified a functional polymorphism at nucleotide 910 of the DBH gene that results in a codon change in the mature protein Ala304S