A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
✍ Scribed by Prokunina, Ludmila; Castillejo-López, Casimiro; Öberg, Fredrik; Gunnarsson, Iva; Berg, Louise; Magnusson, Veronica; Brookes, Anthony J.; Tentler, Dmitry; Kristjansdóttir, Helga; Gröndal, Gerdur
- Book ID
- 109918128
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 175 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng1020
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Objective The A allele of the PD1.3 single‐nucleotide polymorphism (SNP) on the programmed cell death gene PDCD1 was markedly more frequent in patients with systemic lupus erythematosus (SLE) than in unaffected controls in a recent study involving large sets of Swedish, European Ame
In a study of 59 black American patients with systemic lupus erythematosus (SLE), we found that partial C4A deficiency occurred twice as frequently as in 59 control subjects (32.3% versus 15.3%; P = 0.02). Complete C4A deficiency, however, occurred in only 1 patient and in no controls. Partial C4A