A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation

Novel Egr/NF-AT composite sites mediate

Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation

✍ Min Li-Weber; Oskar Laur; Peter H. Krammer 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 202 KB 👁 2 views

Expression of the CD95 (APO-1/Fas) ligand (CD95L) in activated T cells is a major cause of activation-induced T cell apoptosis. The transcription factors NF-AT and Egr-3 (a member of the immediate-early transcription factors involved in cellular growth and differentiation) have been implicated in ac